A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs

Qadir, Anmbiya and Khuroo, Mohammad Akbar and Akbar, Iqrah and Jamal, Parveen (2016) A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur.

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Abstract

β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various compounds as ligands. In this study the binding of β-carboline alkaloids to Bovine Serum Albumin (BSA) has been investigated by using a constant protein concentration and varying drug concentrations. The binding modes of β-carboline alkaloids were analyzed by using FTIR and UV–Vis spectroscopic methods. Spectroscopic evidence showed that β-carboline alkaloids bind BSA via hydrophobic interaction and Vander Waals contacts along with Hbonding with the–NH groups.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	2937/51789
Uncontrolled Keywords:	β-carboline alkaloids, BSA, FTIR, UV-Vis spectroscopy
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	24 Aug 2016 15:17
Last Modified:	19 Oct 2017 21:37
URI:	http://irep.iium.edu.my/id/eprint/51789

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