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Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration

Abdul Majeed, Saif Saad and Saxena, Anil Kumar (2011) Assessment of reactive oxygen species (ROS) status in chronic cerebral hypoperfusion-induced neurodegeneration. In: Enhancing Quality Research and Innovation for Societal Development, 9-10 February 2011, IIUM, Gombak.

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Abstract

Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders, the present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occurs in response to increased oxidative stress following ischemic insult.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 5517/5167
Uncontrolled Keywords: Free radicals, Neurodegeneration, chronic cerebral hypoperfusion, rats
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr. Anil Kumar Saxena
Date Deposited: 09 Nov 2011 15:19
Last Modified: 22 Nov 2011 00:19
URI: http://irep.iium.edu.my/id/eprint/5167

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