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Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort

Lua, Pei Lin and Zakaria, Noor Salihah and Mamat, Nik Mazlan (2016) Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort. Malaysian Journal of Public Health Medicine, 16 (1). pp. 129-136. ISSN 1675–0306

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Abstract

A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 women diagnosed with breast cancer and have been treated by anthracycline-based chemotherapy between 2005 and 2011were included.A weight change (WC) was calculated based on relative percentage of weight changes from baseline to post-chemotherapy and categorized into either weight change (WC >5%) or stable (±5% WC).Survival probabilities were estimated using the Kaplan-Meier (SPSS 20). Upon treatment completion, 42.9% of the women experienced weight changes. A small weight reduction was observed (61.1 ± 11.6kg to 60.2 ± 11.9kg; -0.8 ± 4.0kg; p=0.106). The median EFS of women who experienced weight change was shorter (median 61.0 months) compared to those who maintained their weight (median 89.0 months) (p=0.044). In this study, weight changes during breast cancer chemotherapy were associated with poorer prognosis in comparison to women who maintained their weight.

Item Type: Article (Journal)
Additional Information: 4617/51566
Uncontrolled Keywords: Breast cancer, Chemotherapy, Retrospective study, Weight changes
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User: Dr Nik Mazlan Mamat
Date Deposited: 12 Aug 2016 16:07
Last Modified: 18 Apr 2017 12:15
URI: http://irep.iium.edu.my/id/eprint/51566

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