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Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice

Ridzwan, Irna Elina and Suhaimi, Maryam Saadah and Muhamad, Abdul Halim and Kasmuri, Abdul Razak and Mohamed Nazar, Nor Ilyani and Hashim, Ridzwan and Syd Mohmad Faudzi, Syed Mohd Syahmi (2018) Low-dose methamphetamine addiction induced opioid receptor sensitization in polydrug-dependent mice. In: Regional Conference on Science Technology & Social Sciences (RCSTSS2016), 4th-6th December 2016, Cameron Highlands, Pahang.

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Abstract

Polydrug dependence shows an increasing trend in prevalence among addicts. It is a result of an addict abusing another drug to mask the undesirable effects of another drug. However, this could lead to adverse neuroadaptations. Therefore, we aim to investigate the effects of low-dose methamphetamine use in morphine-dependent subjects during reinstatement following treatment (0.3 mg/kg buprenorphine / 1.0 mg/kg naltrexone combination) in mice. Using tail-withdrawal assay, the involvement of opioid receptors was investigated at 1.0-5.0 mg/kg methamphetamine, i.p. at 52°C. The results showed that analgesic activity was only detected at the highest dose given which was successfully blocked with 1.0 mg/kg naltrexone, i.p. (p<0.001, n=6). Next, naive mice were randomly divided into three groups (n=at least 12), where the mice were made dependent (p<0.01) to morphine (7.5 mg/kg, i.p.), methamphetamine (1.0 mg/kg, i.p) or morphine/methamphetamine combination (7.5 mg/kg and 1.0 mg/kg respectively). Although relapse was successfully attenuated with non-significant difference compared to baseline, it was found that 6 (out of 13) mice showed sign of opioid receptor sensitization through stereotype and Straub's tail response (>45°) which was not detected in the morphine-, methamphetamine-dependent groups and during pre-screening of treatment drug. This suggest that although methamphetamine has little apparent withdrawal symptoms, it has the ability to sensitize the opioid receptors even at 'inactive' dose when it is used concurrently with morphine.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 5628/51526
Uncontrolled Keywords: Methamphetamine, Polydrug, Opioid Receptor
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences
Kulliyyah of Pharmacy
Depositing User: Dr Irna Elina Ridzwan
Date Deposited: 12 Aug 2016 11:08
Last Modified: 30 Jul 2018 14:50
URI: http://irep.iium.edu.my/id/eprint/51526

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