Label-free microfluidic blood cells micro-separator

Aissa, Foughalia and Ibrahim, Siti Noorjannah (2016) Label-free microfluidic blood cells micro-separator. In: 2016 Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP), 30th May-2nd June 2016, Budapest, Hungary.

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Abstract

Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate white blood cells (WBCs) and red blood cells (RBCs) by taking into account the magnetization of the ferromagnetic elements and fluidic forces on the cells. The microfluidic devices can achieve label-free, continuous separation of WBCs and RBCs with relatively high efficiency. The micro-separator utilizes hydrodynamic force acting on cells within laminar flow, coupled with magnetophoresis force in novel U-shaped micro-channel. Here, we report the separation efficiency of the microfluidic device in continuous flow based on results of a 3D model simulation conducted in COMSOL Multiphysics. The proposed device enables label-free cell separation and thus, it can be a useful microfluidic component for lab-on-a-chip system and integrated biological and biomedical applications.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	3823/51267
Uncontrolled Keywords:	Microfluidic; Simulation; Magnetophoresis; Bio- Analysis; Hydrodynamic, Cell Separation; Multiphysics
Subjects:	T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK452 Electric apparatus and materials. Electric circuits. Electric networks T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices > TK7885 Computer engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Electrical and Computer Engineering
Depositing User:	Siti Noorjannah Ibrahim
Date Deposited:	26 Jul 2016 15:35
Last Modified:	10 Jan 2017 11:19
URI:	http://irep.iium.edu.my/id/eprint/51267

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