Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study

Al-Jaufi, Fakhria and Al-Ani, Imad M and Saxena, Anil Kumar and Talib, Norlelawati A. and H. Mokhtar, Rafidah and Ku-Zaifah, Norsidah (2016) Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study. European Journal of Anatomy, 20 (2). pp. 131-136. ISSN 1136-4890 E-ISSN 2340-311X

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Abstract

The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure.

Item Type:	Article (Journal)
Additional Information:	5849/50698
Uncontrolled Keywords:	Atherosclerosis,Intima media thickness, Aorta, High fat diet, Rats, Tongkat Ali
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr. Anil Kumar Saxena
Date Deposited:	15 Jun 2016 10:46
Last Modified:	04 Apr 2017 10:16
URI:	http://irep.iium.edu.my/id/eprint/50698

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