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Identification of antioxidants in Momordica charantia fruit using GC-MS metabolomics approach

Perumal, Vikneswari and Uzir, Bisha Fathamah and Abas, Faridah and Ahmed, Qamar Uddin and Nik Yusoff, Nik Mohd. Idris and Khatib, Alfi (2016) Identification of antioxidants in Momordica charantia fruit using GC-MS metabolomics approach. In: International Conference on Natural Products 2016 (ICNP 2016), 15th-17th March 2016, Kuala Terengganu, Terengganu, Malaysia. (Unpublished)

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Momorica charantia fruit is one of the herbal plants and food used in Malaysia known as “Peria katak”. This plant has been used traditionally to relieve some disease including diabetes, ulcer, gout, and cough. This study focused on the identification of potential antioxidants in this fruit using GC-MS based metabolomics approach. Six series of solvents including water, 40%, 60%, 80% ethanol in water, and ethanol was used to extract the fruit. GC-MS profiles combined with antioxidant activities (DPPH and FRAP) were calculated using orthogonal partial least square to identify which retention times in GC-MS chromatogram correlate to antioxidant activities. This information was submitted to the NIST database to elucidate which compounds were present. The score plot showed an obvious and remarkable separation into six clusters indicating the six different of metabolite profile of the extracts. The results revealed 8 compounds in this fruit induce the antioxidant activities, while 2 others suppress the bio-activities.

Item Type: Conference or Workshop Item (Other)
Additional Information: 5634/50626
Uncontrolled Keywords: GC_MS, matabolomics, omordica charantia, antioxidant
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Alfi Khatib
Date Deposited: 21 Jun 2016 09:16
Last Modified: 18 Jul 2016 21:52
URI: http://irep.iium.edu.my/id/eprint/50626

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