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Blood-pressure and cholesterol lowering in persons without cardiovascular disease

Yusuf, Salim and Phi, D. and Lonn, Eva and Pais, Prem and Bosch, Jackie and López‑Jaramillo, Patricio and Md Aris, Mohd Aznan and Mohd Shah, Azarisman Shah and ., et. al (2016) Blood-pressure and cholesterol lowering in persons without cardiovascular disease. New England Journal of Medicine, 374 (21). pp. 2032-2043. ISSN 0028-4793

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Abstract

Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially. In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12.5 mg per day) or placebo. In the analyses reported here, we compared the 3180 participants assigned to combined therapy (with rosuvastatin and the two antihypertensive agents) with the 3168 participants assigned to dual placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included heart failure, cardiac arrest, or revascularization. The median follow-up was 5.6 years.

Item Type: Article (Journal)
Additional Information: 4632/50347 This project has more than 440 collaborators.The list of complete collaborators is available in the supplementary document. For repository purpose we have to shortened to IIUM names.
Uncontrolled Keywords: blood-pressure,cholesterol
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
R Medicine > RZ Other systems of medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Internal Medicine
Depositing User: Assoc Prof Dr Mohd Aznan Md Aris
Date Deposited: 04 May 2016 08:54
Last Modified: 05 Jan 2017 05:49
URI: http://irep.iium.edu.my/id/eprint/50347

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