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Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines

Hamidon, Hanisuhana and Bakhtiar, M. Taher and Md. Jaffri, Julian and Tg Zakaria, Tg Muhammad Faris Syafiq and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti and Ichwan, Solachuddin Jauhari Arief and Zakaria, Zainul Amiruddin (2016) Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines. Makara Journal of Health Research, 20 (1). pp. 11-17. ISSN 2356-3664 E-ISSN 2356-3656

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Abstract

Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.

Item Type: Article (Journal)
Additional Information: 5209/50327
Uncontrolled Keywords: Garcinia xanthochymus, Guttiferae, cytotoxicity, anti-inflammatory, in vitro
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Muhammad Taher
Date Deposited: 26 Apr 2016 09:19
Last Modified: 03 Oct 2017 15:25
URI: http://irep.iium.edu.my/id/eprint/50327

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