Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience

Shahar, Mohammad Arif and Omar, Ahmad Marzuki and AbAziz, Aini and Rajoo, Subashini and Loh, Huai Heng and Ooi, Chew Peng and Wan Seman, Wan Juani and Omar, Mohd Rahman and A Wahab, Norasyikin and Zainuddin, Suehazlyn and Mustafa, Norlaila and Sukor, Norlela and Kamaruddin, Nor Azmi (2014) Rate of remission after radio-ablative iodine therapy for thyrotoxicosis: The University Kebangsaan Malaysia Medical Centre (UKMMC) experience. Journal of Endocrinology and Metabolism, 4 (1(Sup)). p. 18. ISSN 2229-9572

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Abstract

Objectives: To describe the rate of remission of thyrotoxicosis after radioablative iodine-131 (RAI) therapy. Methods: This was a retrospective review of 84 thyrotoxic patients who received RAI in the year 2011/2012. Their blood investigations prior and post-RAI therapy were reviewed. Data were analyzed using SPSS 19. Results: Eighty-four patient received RAI therapy in 2011/2012 and was followed-up till March 2014. The mean age of the patients was 45.8 ± 12.8 years. Majority (57.1%) received 12 mCi, 19% received 15 mCi and 23.8% received lower dose (10 mCi) of RAI. Mean thyroxine level prior to RAI was 28.3 ± 12.0 pmol/L, and majority (77.8%) had suppressed TSH (<0.01 mIU/L) and 22.2% had low but detectable TSH (0.01-0.3 mIU/L). Fourtyfive percent (44.9%) remained hyperthyroid at 6 months post RAI (44.2% have suppressed TSH, 55.8% have detectable low TSH). Among those who went into remission at 6 months, 31.6% were euthyroid and 68.4% were hypothyroid. At 12 months 51.2% of patient goes into remission where 39.5% of them were euthyroid and 60.5% were hypothyroid. Half of the patient went into remission by 5 months post RAI therapy. By 24 months, 81.9% had gone into remission. Conclusions: The percentage of remission after RAI therapy at our centre increases with duration. By 24 months RAI induces remission in about 82% of patients

Item Type:	Article (Journal)
Additional Information:	5471/50091
Uncontrolled Keywords:	thyrotoxicosis, radio-ablative iodine therapy,remission
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Mohammad Arif Shahar
Date Deposited:	17 Mar 2016 15:09
Last Modified:	15 Jul 2016 10:53
URI:	http://irep.iium.edu.my/id/eprint/50091

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