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Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives

Atia, Ahmad Elbadry and Ku Zaifah, Norsidah and Abdullah, Nor Zamzila and Mokhtaar, Rafidah Hanim and Md Aris, Mohd Aznan and Draman, Samsul and A.Talib, Norlelawati (2010) Study of Beta 2-Adrenergic Receptor Polymorphisms among Hypertensives. In: 3rd International Conference on Advancement in Science and Technology (ICAST), 26-29 Nov 2010, Vistana Hotel, Kuantan.

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Aims: The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to the hypertensive status. The aim of the present study was to assess the association between ;22AR polymorphisms and hypertension. Methods: In case control study, 100 unrelated patients (50 hypertensive and 50 matched controls) were analyzed for the Arg16Gly and the Gln27Glu polymorphisms by restriction fragment length polymorphism- polymerase chain reaction assay analysis. Results: The genotypes frequencies of the genotypes of the 100 individuals enrolled in the study were: Arg16 (24%); Arg16Gly (45%); Gly16 (31%); Gln27 (83%); Gln27Glu (15%), and Glu27 (2%). The present study found no association between the 2 SNPs, Arg16Gly and Gln27Glu of beta2 adrenergic receptor gene with either hypertensive status or elevated blood pressure. (P value is 0.78 (odds ratio=0.81) and 0.37 (odds ratio=1.81) for Agr16Gly, Gln27Glu respectively). Conclusion: these finding suggest that B2AR SNPs tested are unlikely to confer genetic susceptibility for hypertension status in our population samples

Item Type: Conference or Workshop Item (Poster)
Additional Information: 4667/4972
Uncontrolled Keywords: B2-adrenergic receptor 13 single nucleotide polymorphism- hypertension-blood pressure.
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Depositing User: Dr Norlelawati A.Talib
Date Deposited: 18 Jan 2012 16:34
Last Modified: 11 Nov 2015 09:35
URI: http://irep.iium.edu.my/id/eprint/4972

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