Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum

Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Rezauden (2016) Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum. Journal of Applied Pharmaceutical Science, 6 (1). pp. 23-27. ISSN 2231-3354

	PDF - Published Version Restricted to Repository staff only Download (268kB) | Request a copy
	PDF - Supplemental Material Restricted to Repository staff only Download (44kB) | Request a copy

Abstract

Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 μg/mL and A-549 at 26.41μg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125μg/mL and 62.5μg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals

Item Type:	Article (Journal)
Additional Information:	5209/49565
Uncontrolled Keywords:	Calophyllum symingtonianum, cytotoxic, antibacterial, coumarin, chromanone acid, Guttiferae
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	30 Mar 2016 15:35
Last Modified:	22 Dec 2016 08:16
URI:	http://irep.iium.edu.my/id/eprint/49565

Actions (login required)

View Item