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Solubility prediction of L-ascorbic acid by using COSMO-RS

Hassan, Syajaratul Jahriah and Adam, Fatmawati and Abu Bakar, Mohd. Rushdi (2014) Solubility prediction of L-ascorbic acid by using COSMO-RS. In: International Conference in Industrial Pharmacy 2014, 16th-17th August 2014, Swiss Garden Resort and Spa, Kuantan, Pahang. (Unpublished)

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Abstract

Pharmaceutical is a highly regulated industry based on its nature that involves human life. Every decision must be scientifically sound from the early stage in order to provide security and safety to the patient. Only 1 from 4000 synthesized drugs reach the market which cost about $800-900 million dollar within 8-12 years from discovery to market. Any method that could expedite the research development is highly needed to reduce the development time of newly designed drugs. COSMO-RS is a fast and efficient methodology for predicting the thermodynamic properties of fluids and liquid mixtures that use a statistical thermodynamics approach based on the results of quantum chemical methods (QM) (Klamt & Eckert, 2000). It is programmed based on interacting molecular surface charges. By using COSMO-RS, only melting point and heat of fusion Δh is needed to determine the long and crucial solubility test in any solvent.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 4033/48664
Uncontrolled Keywords: Solubility prediction; COSMO-RS
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Mohd Rushdi Abu Bakar
Date Deposited: 25 Apr 2018 14:53
Last Modified: 25 Apr 2018 14:53
URI: http://irep.iium.edu.my/id/eprint/48664

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