Antimicrobial activities of stembark and wood extracts from Nuclea subdita against pathogenic microorganisms

Jamaluddin, Fatin Ruzanna and Lee, Seng Hua and Ashaari, Zaidon and Wahab, Razak and Mohd Daud, Jamaluddin (2015) Antimicrobial activities of stembark and wood extracts from Nuclea subdita against pathogenic microorganisms. Malaysian Journal of Microbiolog, 11 (4). pp. 365-372. ISSN 1823-8262

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Abstract

The aim of the study was to investigate the antimicrobial activity of Nuclea subdita (Korth) Steud against six pathogenic microorganisms. Methodology and results: Young and maturedtrees ao N. subdita were cut and separated into bark and wood parts, respectively, prior to extraction process. Phytochemical screening tests, antimicrobial activity, minimal inhibitory concentration (MIC) and minimal bacterial concentration (MBC) values were determined. Preliminary screening for phytochemical components showed that both young and matured tree had similar constituents. Extracts from matured tree showed more potency in terms of the zones of inhibition sizes than the young tree. Extract of N. subdita was more potent to both marine bacteria, Vibrio parahaemoliticus and V. alginolyticus, while Candida albican and Aspergillus niger were resistant to it. The sensitivity test showed that 500 ug/mL is the optimum concentration for extract of bottom sapwood of mature tree to act as bactericidal. Conclusion, significance and impact study: The results from this study suggest that N. subdita bark and wood extracts may serve as potential source of antimicrobial agents for future development in medicine applications.

Item Type:	Article (Journal)
Additional Information:	5678/48495
Uncontrolled Keywords:	Nauclea subdita, antimicrobial activity, minimal inhibitory concentration, minimal bactericidal concentration
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Jamaluddin Mohd Daud
Date Deposited:	19 Jan 2016 10:43
Last Modified:	19 Dec 2016 15:55
URI:	http://irep.iium.edu.my/id/eprint/48495

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