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Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats

Ismail, Azlini and Mohamed, M. and Sulaiman, Siti Amrah and Wan Ahmad, W. A. N. (2013) Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats. Evidence-Based Complementary and Alternative Medicine, 2013. pp. 1-16. ISSN 1741-427X

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Abstract

Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia (

Item Type: Article (Journal)
Additional Information: 7407/48151
Uncontrolled Keywords: S. polyanthum,
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Depositing User: DR. AZLINI ISMAIL
Date Deposited: 15 Mar 2016 11:29
Last Modified: 15 Jul 2016 14:18
URI: http://irep.iium.edu.my/id/eprint/48151

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