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Quantum chemical structure activity studies of anticancer activity of seconucleoside nitrosourea analogs

Noorbatcha, Ibrahim Ali and Samsudin, Nurhusna and Mohd. Salleh, Hamzah and Idid, Syed Zahir (2016) Quantum chemical structure activity studies of anticancer activity of seconucleoside nitrosourea analogs. Chemical Informatics, 2 (1). pp. 1-7. E-ISSN 2470-6973

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Nucleosides can be considered as specific carriers for the nitrosourea moiety with altered pharmacological properties such as improved water solubility, lower myelotoxicity with enhanced cell membrane transport. Several seconucleoside nitrosourea compounds have been reported to have anticancer activity against solid tumors such as, murine adenocarcinomas of the colon 13 (MAC 13), MAC 15A, colon 38 and mammary carcinoma. In an effort to have a good understanding of the role of the structural features on the anticancer activity of these seconucleosides, we have constructed the quantitative structure activity relationship (QSAR) involving 26 seconucleoside nitrosourea compounds having anticancer activity against murine adenocarcinomas of the colon 15A (MAC 15). Traditional QSAR studies require knowledge of several physicochemical properties to obtain a good QSAR. To circumvent this problem, we have made use of quantum chemical methods to calculate several electronic and molecular properties of these compounds and used these properties to obtain the best QSAR using statistical procedures. Semi-empirical quantum chemical RM1 methods were used to optimize the molecular structures. From the optimized structure, hundreds of molecular and electronic properties were calculated and correlated with the anticancer activities of the compounds. The best correlation was obtained using heuristic and multi-linear regression methods. We were able to obtain a best QSAR with correlation coefficient, R2=0.8993. We find that the average structural information contents of the second order, average bond order of oxygen atom and maximum columbic interaction for H-N bond play significant roles in influencing the anticancer activity of the selected compounds. The QSAR obtained in our study can be used to predict the anticancer activity of new seconucleoside nitrosourea analogs, prior to resorting to any experimental studies.

Item Type: Article (Journal)
Additional Information: 3704/48147
Uncontrolled Keywords: QSAR; anticancer activity; nucleosides; solid tumors
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
International Institute for Halal Research and Training (INHART)
Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Kulliyyah of Engineering
Depositing User: Dr Hamzah Mohd. Salleh
Date Deposited: 14 Jan 2016 08:18
Last Modified: 07 Nov 2019 14:32
URI: http://irep.iium.edu.my/id/eprint/48147

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