Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia

Md Rosli, Ahmad Nabil and Subbiah, Rakesh and Maniam, T (2014) Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia. ASEAN Journal of Psychiatry, 15 (1). pp. 90-92. ISSN 2231-7791 (O), 1876-2018 (P)

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Abstract

Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed

Item Type:	Article (Case Report)
Additional Information:	6878/47979
Uncontrolled Keywords:	Clozapine, Clozapine Re-challenge, Lithium, Neutropenia
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Mr Aidil Faszrul Abdul Rahim
Date Deposited:	15 Mar 2016 08:52
Last Modified:	25 Jun 2018 08:24
URI:	http://irep.iium.edu.my/id/eprint/47979

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