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Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals

Yusof, Faridah and Mehde, Atheer Awad and Mehdi, Wesen Adel and Ahmad Raus, Raha and Ghazali, Hamid and Abdul Rahman, Azlina (2015) Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals. Biomedical and Environmental Science, 28 (9). pp. 660-665. ISSN 0895-3988

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Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01). Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.

Item Type: Article (Journal)
Additional Information: 3911/47808
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Dr Raha Ahmad Raus
Date Deposited: 11 Jan 2016 14:55
Last Modified: 23 May 2018 09:57
URI: http://irep.iium.edu.my/id/eprint/47808

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