Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations

Abd Halim, Khairul Bariyyah and Koldsoe, Heidi and Sansom, Mark S.P. (2015) Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations. Biochimica et Biophysica Acta, 1850 (5). pp. 1017-1025. ISSN 0304-4165

PDF - Published Version Restricted to Repository staff only Available under License Creative Commons Attribution. Download (2MB) | Request a copy

Abstract

The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell membrane.Multiscale MD simulations were used to characterize PIP2-JM interactions. Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids.

Item Type:	Article (Journal)
Additional Information:	7228/47685
Uncontrolled Keywords:	EGFR; Juxtamembrane domain; PIP2; Molecular dynamics; Lipid bilayer
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Khairul Bariyyah Abd Halim
Date Deposited:	15 Jan 2016 13:57
Last Modified:	26 Oct 2017 15:23
URI:	http://irep.iium.edu.my/id/eprint/47685

Actions (login required)

View Item