Analgesic synergism of gabapentin and carbamazepine in rat model of diabetic neuropathic pain

Abdullah Al-Mahmood, Sinan Mohammed and Che Abdullah, Shahrin Tarmizi and Nik Ahmad, Nik Nur Fatnoon and Mohamed, Abdul Hadi and Abdul Razak, Tariq (2016) Analgesic synergism of gabapentin and carbamazepine in rat model of diabetic neuropathic pain. Tropical Journal of Pharmaceutical Research, 15 (6). pp. 1191-1195. ISSN 1596-5996 E-ISSN 1596-9827

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Abstract

Purpose: To evaluate synergy in the analgesic effects of a combination therapy of carbamazepine (CBZ) and gabapentin (GBP) in diabetic neuropathic pain. Methods: Neuropathic pain was produced in rats by a single intraperitoneal injection of streptozotocin (STZ) at 60 mg/kg. CBZ, GBP, and their combination were orally administered at varying doses (GBP 30 - 180 mg/kg; CBZ 20 - 40 mg/kg) comparable to their therapeutic doses in humans. Nociceptive responses in the diabetic rats were assessed using hot plate test. Results: Hot plate latency significantly increased with oral administration of GBP at a dose of 180 mg/kg when compared with control group (p < 0.05), while at a dose of 90 mg/kg, the increase was not significant. Oral administration of CBZ at doses of 20 and 40 mg/kg did not produce any significant impact on hot plate latency. However, a combination of GBP at 90 mg/kg and CBZ at 20 mg/kg produced significant increase in latency, compared with control group and other groups (p < 0.05), except the group that received 180 mg/kg GBP. The combination of low dose GBP 30 mg/kg and carbamazepine 30 mg/kg had no significant effect on latency (p > 0.05). Conclusion: The results obtained in this study provide useful information on the combination therapy of GBP and CBZ, which may be applied in the treatment of pain in diabetic neuropathy.

Item Type:	Article (Journal)
Additional Information:	7037/47664
Uncontrolled Keywords:	Diabetic neuropathy, Carbamazepine, Gabapentin, Hot-plate test
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User:	Mr SINAN AL-MAHMOOD
Date Deposited:	11 Jul 2016 08:59
Last Modified:	21 Mar 2017 16:58
URI:	http://irep.iium.edu.my/id/eprint/47664

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