In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)

Mohd Shafri, Mohd Affendi and Yusof, Fathin Athirah and Md Zain, Ahmad Zulkarami (2015) In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl). Jurnal Teknologi, 77 (3). pp. 7-11. ISSN 0127–9696 E-ISSN 2180–3722

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Abstract

Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment.

Item Type:	Article (Journal)
Additional Information:	6845/47438
Uncontrolled Keywords:	Ferula assafoetida, cytotoxicity, anti-cancer
Subjects:	UNSPECIFIED
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Dr Mohd Affendi Mohd Shafri
Date Deposited:	05 Jan 2016 18:24
Last Modified:	15 Jul 2016 10:14
URI:	http://irep.iium.edu.my/id/eprint/47438

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