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Ion-selective electrode biochip for applications in a liquid environment

Wan Salim, Wan Wardatul Amani and Hermann, Andrew C. and Zietchek, Michael Z. and Pfluger, Jonathan P. and Park, Joon H. and ul Haque, Aeraj and Sanober, Fahmi and Porterfield, Marshall D. (2016) Ion-selective electrode biochip for applications in a liquid environment. In: International Conference for Innovation in Biomedical Engineering and Life Sciences (ICIBEL2015), 6 - 8 December 2015, Putrajaya, Malaysia.

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Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurements were performed in a custom-made flow-cell chamber. The results of potentiometric measurement of cationic analytes demonstrate the electrodes to have a near-Nernstian slope profile even after they are stored for almost a month in liquid medium. The electrodes also achieved H2O2 amperometric sensitivity (1.25 and 3.32 µAmM-1cm-2 for PEDOT:PSS and PEDOT:CaSO4 respectively) and lower detection limit (2.21 µM, 8.4 µM, 3.44 µM, for H+, NH4+, Ca2+ respectively) comparable to that of wire-type electrodes. Furthermore, the lifetime is dependent on the electrodeposition method of the conductive polymer, and the transducer layer must be modified to fit the analyte types. These results indicate that extended lifetime of microfabricated ion-selective electrodes in a multiplex format can be realized by optimizing the microfabricated electrode surface functionalization.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 7116/47221
Uncontrolled Keywords: electrochemical sensor, all-solid-state ion-selective electrode, PEDOT, lab-on-a-chip
Subjects: T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Dr Wan Wardatul Amani Wan Salim
Date Deposited: 02 Feb 2016 10:25
Last Modified: 20 Oct 2017 12:10
URI: http://irep.iium.edu.my/id/eprint/47221

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