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Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis

Ibrahim, Wisam Nabeel and Ku Zaifah, Norsidah and Draman, Samsul and Abdullah, Nor Zamzila and Mokhtar, Rafidah Hanim and A.Talib, Norlelawati (2015) Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis. The International Medical Journal Malaysia, 14 (2). pp. 39-46. ISSN 1823-4631

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Introduction: Essential hypertension is a multifactorial disease. Many experimental studies have elucidated the role of oxidative stress and atherosclerosis in the pathogenesis of essential hypertension. Apolipoprotein E is a plasma protein that is found to have antioxidant properties, and it also protects against atherosclerosis. Interestingly, the biological function of apolipoprotein E is strongly affected by polymorphisms in its gene. Based on this evidence, our aim was to investigate the association of apolipoprotein E gene polymorphisms with essential hypertension. Methods: This study was conducted on 70 hypertensive patients and 73 control participants recruited from the Balok governmental health clinic in Kuantan, Pahang. The polymerase chain reaction restriction fragment length polymorphism assay (PCR-RFLP) was used for determination of the apolipoprotein E genotype. Our results were also verified later by direct sequencing of the amplicons. Results: There was no significant association of apolipoprotein E allele or genotype frequencies with hypertensive disease or blood pressure levels, although the E4 allele was slightly more frequent in the hypertensive patients than in the control group (OR=1.055; 0.471–2.359, CI 95%). To improve the precision of the study and to settle the controversies among similar studies meta-analysis was performed; however it revealed a net nonsignificant association between the apolipoprotein E4 allele with essential hypertension in the combined population. Conclusion: Our data and the meta-analysis findings provide evidence that apolipoprotein E gene polymorphism has no direct significant association with hypertension.

Item Type: Article (Journal)
Additional Information: 6715/46069
Uncontrolled Keywords: Apolipoprotein E, essential hypertension, single nucleotide gene polymorphism
Subjects: Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Nursing
Depositing User: Dr Wisam Nabeel
Date Deposited: 08 Dec 2015 09:32
Last Modified: 16 Jun 2017 10:17
URI: http://irep.iium.edu.my/id/eprint/46069

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