Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin

Sharif, Mohd. Faez and Hamid, Muhajir and Ismail, Amin and Adam, Zainah (2015) Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin. Jurnal Sains Kesihatan Malaysia, 13 (2). pp. 37-43. ISSN 1675-8161

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Abstract

Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. Aktiviti hipoglisemik dan antihiperglisemik ekstrak buah kelapa sawit Elaeis guineensis terhadap tikus normal dan tikus diabetik aruhan- Streptozotocin dikaji. Ekstrak minyak buah kelapa sawit (OPF) diberi secara oral pada kepekatan berbeza (100, 200 dan 500 mg kg-1 b.w.) kepada tikus puasa dan posprandial. Hipoglisemia tidak berlaku dalam kumpulan tikus normal yang dirawat dengan OPF. Dalam tikus puasa, OPF (500 mg kg-1 b.w.) telah menyebabkan aras glukosa darah (BGL) turun secara bererti. Bagi tikus diabetik posprandial, aktiviti anti hiperglisemik telah diperhatikan selepas rawatan OPF pada kepekatan 200 dan 500 mg kg-1. Rawatan OPF secara kronik (selama 28 hari) meningkatkan berat badan tikus diabetik dan menurunkan BGL secara bererti serta memperbaiki rembesan plasma insulin. Keputusan kajian ini mencadangkan, ekstrak buah kelapa sawit E. guineensis menunjukkan sifat antihiperglisemik dengan penurunan BGL tikus diabetik.

Item Type:	Article (Journal)
Additional Information:	7129/45898
Uncontrolled Keywords:	Elaeis guineensis; oil palm fruit extract; blood glucose level; hypoglycaemic; antihyperglycemic, Elaeis guineensis; ekstrak buah kelapa sawit; aras glukosa darah; hipoglisemik; antihiperglisemik
Subjects:	Q Science > QH Natural history > QH301 Biology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	MOHD FAEZ SHARIF
Date Deposited:	25 Nov 2015 11:22
Last Modified:	29 Nov 2017 15:19
URI:	http://irep.iium.edu.my/id/eprint/45898

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