Metabolomics for bioactivity assessment of natural products

Khatib, Alfi (2015) Metabolomics for bioactivity assessment of natural products. In: The 49th Pokjanas TOI International Seminar, 21-22 October 2015, Faculty of Pharmacy, Jakarta, Indonesia.

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Abstract

Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal biofluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	6915/45724
Uncontrolled Keywords:	natural product;drug discovery;bioactivity;metabolomics
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	16 Nov 2015 10:50
Last Modified:	24 May 2016 08:41
URI:	http://irep.iium.edu.my/id/eprint/45724

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