Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres

Rahman, Md. Mokhlesur and Ansary, Rezaul Haque and Katas, Haliza and Ab. Hadi, Hazrina and Mohamed, Awang (2015) Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres. In: Controlled Release & Drug Delivery Symposium 2014 (CRDDS 2015), 23rd-24th Aug. 2015, Kuala Lumpur Campus, Kuala Lumpur. (Unpublished)

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Abstract

The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA microspheres. Double-walled microspheres were prepared by a modified water-in-oil-in-oil-in-water (w/o/o/w) emulsion solvent evaporation method. The prepared double-walled microspheres were non-porous, smooth surfaced, and spherical in shape. A significant reduction of the initial burst release of insulin was achieved from the prepared double-walled microspheres. Moreover, a sustained and complete release of insulin without any lag phase was achieved in this study. Thus, double-walled microspheres can be a potential delivery system of therapeutic insulin.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5269/44964
Uncontrolled Keywords:	insulin-loaded, double-walled poly, lactide-co-glycolide, microspheres
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Mohd Mokhlesur Rahman
Date Deposited:	21 Oct 2015 10:16
Last Modified:	12 Oct 2017 10:37
URI:	http://irep.iium.edu.my/id/eprint/44964

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