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A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients

Tin, Myo Han and Swe, Swe Latt and Osman, Iskandar Firzada and Thuraiappah, Daniel M and Aung , Gyi and Md Aris, Mohd Aznan and Abdullah, Fa’iza and Tin, Tin Aye (2015) A meta-analysis on the accuracy of dengue diagnostic tests used for point-of-care testing (POCT) in ASEAN patients. In: 4th Asia Pacific Conference on Public Health 2015, 7-9- Sep 2015, Kuantan, Malaysia.

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Abstract

Introduction: ASEAN countries are included in the 30 most highly dengue endemic countries in the world. Evaluation of the accuracy of dengue diagnostic tests is essential for clinical management, surveillance, control activities and vaccine development. Aim of this study is to review the accuracy of diagnosis tests used for POCT for dengue infection. Methods: The accuracy results of 31 dengue diagnosis tests in 5308 ASEAN patients except Brunei were extracted from 14 articles published within 2007 and 2014. Rapid diagnosis tests (RDT) and WHO-Clinical criteria were considered for POCT. ELISA tests with/without WHO-Clinical criteria were included in meta-analysis. Pooled sensitivity (SN) and specificity (SP) were computed. Egger-bias was analysed for publication bias. Results: Pooled (range) SN of NS1(RDT) , IgM/IgG(RDT) , NS1+IgM/IgG (RDT) and WHO-Clinical criteria were 65% (44-79), 14% (3-50) ,80% (69-86) and 93% (80-97) while SP (range) of those tests were 99% (96-100), 97% (93-99), 96% (84-98) and 34% (20-57 )respectively. Pooled (range) of SN and SP of NS1 (ELISA) were 64% (45-82) and 99% (93-100. SN /SP (95% CI) of IgM/IgG (ELISA) were 50% (40-60) / 100% (96-100) and those of NS1+IgM/IgG (ELISA) were 94% (89-97)/92 % (81-97) and those of NS1+IgM/IgG (ELISA) with WHO -Clinical criteria were 91% (86-95)/ 94 % (84-98) respectively. Egger-bias was significant (p<0.0001). Discussion and conclusion: Both RDT and ELISA tests have high SP to rule in dengue diagnosis. Wide range of SN value (WHO-Clinical Criteria vs IgM/IgG RDT) highlighted to improve SN of the tests for ruling out. Added value of dengue epidemic information in the accuracy of the tests should be verified. A multi-centred study with a standardized protocol should be conducted for diagnostic test accuracy variation for POCT among ASEAN patients.

Item Type: Conference or Workshop Item (Plenary Papers)
Additional Information: 6249/44802 ISSN 0300-5283 Abstract
Uncontrolled Keywords: meta-analysis, dengue diagnostic tests, point-of-care testing, POCT, ASEAN
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Depositing User: Dr Tin Myo Han
Date Deposited: 22 Sep 2015 08:54
Last Modified: 20 Jul 2016 14:35
URI: http://irep.iium.edu.my/id/eprint/44802

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