Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis

Ahmad Rafani, Fikri and Mohammad Subri, Abdul Hadi and Mohd Sabri, Muhammad Farhan and Robson Brown, Kate and Sharif, Mohammed and Zamli, Zaitunnatakhin (2015) Temporal and topographical variation of subchondral bone changes in a spontaneous animal models of osteoarthritis. The Malaysian Journal of Microscopy, 11 (supp.1). p. 46. ISSN 1823-7010

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Abstract

Background: Osteoarthritis (OA) is a common form of arthritis that affects major joint structures including the subchondral bone plate (Sbp) and trabecular bone (Tb). Previous studies have shown that the patterns of subchondral bone (Sb) changes in the medial and lateral sides of tibial epiphysis, in both human and animal models of OA are different. The aim of the current study is to investigate detailed structural changes of Sbp and Tb in sub-regions within each side of the tibia during the initiation and progression of OA in Dunkin Hartley (DH) which develop OA around 12 weeks of age and Bristol Strains 2 (BS2) guinea pigs that develop OA around 24 weeks. Methods: The micro-computed tomography (Micro-CT) images of the proximal part of the right tibia of six males DH (n=24) and BS2 (n=24) guinea pigs were obtained from previous study, and collected at 10, 16, 24, and 30 weeks of age. Micro-CT analyzer software was used to quantify the Sbp thickness (SbpTh); Tb morphometric and bone mineral density (BMD) in four sub-regions (i.e. anteromedial, anterolateral, posteromedial, and posterolateral) within each side of the tibial epiphysis. The data were then compared between anterior and posterior sub-regions, the medial and lateral sub-regions, and time points. Results: Sb changes in the four sub-regions were generally more prominent in the medial than lateral side, and in the DH than BS2. In the medial side of the tibia, the posteromedial or PMM sub-region of DH showed a significantly greater of SbpTh [PMM: 463.43

Item Type:	Article (Journal)
Additional Information:	5401/44631
Uncontrolled Keywords:	subchondral bone
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Basic Health Sciences (Until June 2011)
Depositing User:	Zaitunnatakhin Zamli
Date Deposited:	14 Sep 2015 15:59
Last Modified:	14 Jul 2022 12:18
URI:	http://irep.iium.edu.my/id/eprint/44631

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