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Tissue injury characterization by pre-contrast T1 mapping post myocardial infraction

Mohd Shah, Azarisman Shah and Li, Andrew and Wong, Dennis T. and Richardson, James D. and Chua, Seng Keong and Samaraie, Luay and Sidharta, Samuel L and Glenie, Timothy and Williams, Kerry and Koschade, Ben and Teo, Karen and Worthley, Matthew and Worthley, Stephen G. (2013) Tissue injury characterization by pre-contrast T1 mapping post myocardial infraction. Journal of Cardiovascular Magnetic Resonance, 15 (supp.1). E33. ISSN 1532-429X

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Abstract

Background Myocardial scar and edema can be assessed by late gadolinium enhancement (LGE) and T2W cardiac magnetic resonance (CMR) respectively, but each has important limitations. T1-mapping has emerged as an alternative method to characterize acute ischemic injury and contemporary mapping sequences make this clinically feasible. We assessed the T1 relaxation time in myocardial segments exhibiting varying degrees of ischemic injury in patients after acute MI. Methods T2W, T1-mapping (using Shortened Modified Look-Looker Inversion recovery sequence) and LGE imaging was performed 24-72 hours after MI on a 1.5T scanner. Assessment of acute segmental damage, in a 16-segment AHA model, was performed on matched short axis slices. Mean segmental T1 values were calculated for infarcted, adjacent/edema, microvascular obstruction (MVO) or remote segments as defined by LGE.

Item Type: Article (other)
Additional Information: 3808/44312
Uncontrolled Keywords: tissue injury
Subjects: R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Internal Medicine
Depositing User: Mrs Noor Azlin Asnam
Date Deposited: 21 Aug 2015 01:26
Last Modified: 21 Aug 2015 01:26
URI: http://irep.iium.edu.my/id/eprint/44312

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