Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes

How, Fiona Ni Foong and Crouse, Karen A. and M. Tahir, M. Ibrahim and Tarafder , M.T.H. and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes. Polyhedron, 27. pp. 3325-3329. ISSN 0277-5387

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Abstract

S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.

Item Type:	Article (Journal)
Additional Information:	6467/44289
Uncontrolled Keywords:	Dithiocarbazate; Metal complex; Bidentate ligand; Bis-chelated
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Fiona How
Date Deposited:	05 Oct 2015 09:08
Last Modified:	17 Aug 2017 16:10
URI:	http://irep.iium.edu.my/id/eprint/44289

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