Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia

Samsuddin, Niza and Rampal, Krishna Gopal and Ismail, Noor Hassim and Abdullah, Nor Zamzila and Nasreen, Hashima E (2015) Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia. American Journal of Hypertension, 29. pp. 1-8. ISSN 0895-7061 E-ISSN 1941-7225

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Abstract

BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.

Item Type:	Article (Journal)
Additional Information:	3750/44176
Uncontrolled Keywords:	diastolic blood pressure; hypertension; oxidized low-density lipoprotein; paraoxonase 1; pesticides; systolic blood pressure
Subjects:	R Medicine > RA Public aspects of medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Niza Samsuddin
Date Deposited:	24 Aug 2015 15:48
Last Modified:	23 Nov 2017 15:42
URI:	http://irep.iium.edu.my/id/eprint/44176

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