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Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukimia

Kaderi, Mohd Arifin and Mansouri, Mahmoud and Zainuddin, Norafiza and Cahill, Nicola and Gunnarsson, Rebeqa and Jansson, Mattias and Kimby, Eva and Aleskog, Anna and Lundin, Jeanette and Glimelius, Bengt and Melbye, Mads and Juliusson, Gunnar and Jesper Jurlander, Jesper and Rosenquist, Richard (2010) Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukimia. Leukemia Research, 34 (3). pp. 335-339. ISSN 0145-2126

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Abstract

The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL patients and correlated the results with established CLL prognostic factors, time to treatment and overall survival. In this Swedish cohort, no association existed between any particular MDM2 SNP309 genotype, overall survival and time to treatment. Furthermore, no correlation was shown between the MDM2 SNP309 genotypes and Binet stage, IGHV mutational status and recurrent genomic aberrations. In summary, this study argues against the use of the MDM2 SNP309 as a prognostic marker in CLL.

Item Type: Article (Journal)
Additional Information: 4643/4408
Uncontrolled Keywords: MDM2 SNP309, Chronic lymphocytic leukemia, Binet stage, IGHV mutational status, Genomic aberrations, Prognostic markers
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Basic Health Sciences (Until June 2011)
Depositing User: Dr. Norafiza Zainuddin
Date Deposited: 27 Oct 2011 14:57
Last Modified: 14 Dec 2011 20:43
URI: http://irep.iium.edu.my/id/eprint/4408

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