Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres

Rahman, Md. Mokhlesur and Rezaul Haque, Ansary and Mohamed, Awang and Katas, Haliza (2015) Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres. In: Research Acculturation Collaborative Effort, Colloquim 2015, 13 - 14 January 2015, Barder Enstek, Negeri Sembilan. (Unpublished)

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Abstract

In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience, poly(lactide-co-glycolide) (PLGA) based sustained release formulation of insulin delivery has been developed [2]. Generally, the major drawbacks in the development of insulin loaded PLGA microspheres are the high initial burst and incomplete release of encapsulated insulin [3]. Initial burst release means the release of insulin within 24 hours of release studies. Moreover, PLGA microspheres tend to have a very slow or near to zero release of insulin after the initial burst. The slow or no release period is often referred to as the “lag phase” and continues until extensive degradation of PLGA starts. During this period, the patient may not be effectively treated due to the lack of sufficient insulin release [4]. In this study, insulin encapsulated PLGA microspheres have been prepared using a fast degrading hydroxyl terminated–PLGA (PLGA-OH) to reduce the initial burst release and to remove the lag phase with a view to achieve controlled release of insulin.

Item Type:	Conference or Workshop Item (UNSPECIFIED)
Additional Information:	5269/43498
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Mohd Mokhlesur Rahman
Date Deposited:	30 Jul 2015 11:55
Last Modified:	21 May 2018 10:29
URI:	http://irep.iium.edu.my/id/eprint/43498

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