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Cytotoxicity effect of melastoma malabatricum on skin melanoma and cervical cancer in vitro

Ahmad Roslen, Nurfariza and Zainuddin, Norafiza and Kaderi, Mohd Arifin and Abdull Rasad, Mohammad Syaiful Bahari (2013) Cytotoxicity effect of melastoma malabatricum on skin melanoma and cervical cancer in vitro. The Open Conference Proceedings Journal, 4. p. 249. ISSN 2210-2892

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Abstract

Melastoma Malabatricum is a local shrub, commonly known as senduduk that belongs to the family of Melastomataceae. The aim is to evaluate the potential anticancer activities of the different extracts from M. malabathricum. In this study, petroleum ether and chloroform were used in the extraction of stems and flowers of M. malabathricum. The extracts were tested for cytotoxic activity against skin melanoma cancer cell lines (A375) and cervical cancer cell lines (HeLa). Petroleum ether extracts of stem (PeMMS) showed significant growth inhibition of A375 cell lines, followed by the extract of flower (PeMMF). Meanwhile, PeMMF showed less significant growth inhibition of HeLa cell lines, followed by PeMMS. As for the chloroform extracts of stem (CHMMS) and flower (CHMMF), it does not inhibit the growth of both cell lines.

Item Type: Article (Journal)
Additional Information: 4623/43457
Uncontrolled Keywords: Melastoma malabathricum, Petroleum ether extract, Chloroform extract, Anticancer
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr. Norafiza Zainuddin
Date Deposited: 22 Jun 2015 10:28
Last Modified: 24 Jul 2015 09:41
URI: http://irep.iium.edu.my/id/eprint/43457

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