Association of SLC6A4 gene polymorphisms with Schizophrenia

Aladzemi, Farah Wahida and Ku Zaifah, Norsidah and Abdullah, Kartini and Musa, Ramli and Abdul Razak, Tariq and Abdullah, Nor Zamzila and A.Talib, Norlelawati (2015) Association of SLC6A4 gene polymorphisms with Schizophrenia. In: 2nd International Conference on Advances in Medical Sciences (ICAMS) 2015, 14th -16th April 2015, Concorde Hotel, Kuala Lumpur. (Unpublished)

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Abstract

Introduction: The SLC6A4 gene encode for serotonin transporter which regulates synaptic concentration of serotonin thus influences perception, mood, emotion, behavior, and cognition which are the main symptoms of Schizophrenia (Sz). This study investigated the association of SNPs within SLC6A4 gene with Sz. Methods: A total of 240 Sz patients and 364 normal controls were studied. Genomic DNA was extracted from peripheral blood. Rs12449783, rs140700, rs6352 and rs6354 were selected and genotyped using allelic discrimination real time Taqman® assay. Results: A significant association was found between rs12449783 of SLC6A4 gene and Sz for both alleles and genotypic frequencies (p = 1.68 x 10−8 and 5.11 x 10−7 respectively). Conclusion: The significant association between rs12449783 of SLC6A4 gene in our Sz samples reaffirmed the previous similar findings in other population thus support role of SLCA4 gene in Sz.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	3616/42999
Uncontrolled Keywords:	SLC6A4 gene polymorphisms, Schizophrenia
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Dr Norlelawati A.Talib
Date Deposited:	24 Jun 2015 14:11
Last Modified:	24 Jun 2015 14:11
URI:	http://irep.iium.edu.my/id/eprint/42999

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