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Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering

Chahal, Sugandha and Hussain, Fathima Shahitha Jahir and Kumar, Anuj and M. Yusof, Mashitah and Abdull Rasad, Mohammad Syaiful Bahari (2015) Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering. RSC Avances, 5. pp. 29497-29504.

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Abstract

The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for different period of times. After 24h of incubation, the nanofibers were uniformly coated by a thin layer of mineral deposit. SEM, FTIR, and FESEM-EDS analysis confirm the deposition of CaP on the nanofibers. The nanostructured biomaterial maintained its fibrous and porous structure after mineralization. The XRD results suggest that the deposited mineral phase is a mixture of calcium phosphate hydrate and apatite. The mechanical properties of CaP coated scaffolds has similar tensile strength and elastic modulus with that of trabecular and proximal femoral bones. The cytocompatibility of the CaP coated HEC/PVA scaffolds were evaluated using human osteosarcoma cells. The CaP coated HEC/PVA scaffolds supports cellular attachment and proliferation of osteosarcoma cells and will be a promising candidate for bone tissue engineering.

Item Type: Article (Journal)
Additional Information: 4701/42926
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User: Dr. Mohammad Syaiful Bahari Abdull Rasad
Date Deposited: 21 May 2015 08:38
Last Modified: 08 Nov 2017 12:34
URI: http://irep.iium.edu.my/id/eprint/42926

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