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Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children

Kukreja, Ruchi and Saxena, Anil Kumar and Gurtu, Sunil and Ali, Bashir and Sitholey, Prabhat (2011) Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children. The International Medical Journal Malaysia, 10 (1). pp. 31-35. ISSN 1823-4631

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Abstract

Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity (AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this condition.

Item Type: Article (Journal)
Additional Information: 5517/4276
Uncontrolled Keywords: Attention deficit hyperactivity disorder, oxidation-reduction, free radicals, catalase, antioxidants
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User: Dr. Anil Kumar Saxena
Date Deposited: 31 Oct 2011 09:54
Last Modified: 04 Jan 2012 14:47
URI: http://irep.iium.edu.my/id/eprint/4276

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