Comparison of diabetic and non-diabetic patients undergoing endovascular revascularization for peripheral arterial disease

Michael, S. Lee and Seung, Woon Rha and Seung, Kyu Han and Byoung, Geol Choi and Choi, Se Yeon and Ali, Jabar and Xu, Shaopeng and Ngow, Harris Abdullah and et al., (2015) Comparison of diabetic and non-diabetic patients undergoing endovascular revascularization for peripheral arterial disease. The Journal of Invasive Cardiology, 27 (3). pp. 167-171. ISSN 1042-3931

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Abstract

Peripheral arterial disease (PAD) is associated with poor outcomes. We assessed the clinical outcomes of diabetic versus non-diabetic patients with PAD who underwent peripheral transluminal angioplasty (PTA). The outcomes of 239 consecutive patients with symptomatic PAD who underwent PTA were analyzed. Restenosis and clinical outcomes were assessed at a follow-up of 2 years. Diabetic patients had a higher percentage of wound as the initial diagnosis for PTA (72.7% vs 14.2%; P<.001), chronic kidney disease (26.7% vs 6.3%; P<.01), need for dialysis (19.3% vs 3.1%; P<.01), and coronary artery disease (67.6% vs 50.7%; P=.02). Infrapopliteal PTA was more commonly performed in the diabetic group (70.4% vs 25.3%; P<.001). Diabetic patients had lower rates of angiographic follow-up at 8 months (38.6% vs 60.3%; P<.01). Diabetic patients had higher binary restenosis (54.4% vs 31.5%; P=.02) and had a trend toward a higher incidence of total occlusion (34.0% vs 19.5%; P=.08). At 2-year follow-up, the amputation rate was higher in the diabetic group (24.4% vs 1.5%; P<.001) despite PTA. Diabetic patients more frequently presented with critical limb ischemia compared with non-diabetic patients and had higher rates of restenosis and amputation at 2 years following standard PTA. Improved therapies are needed for this high-risk group of patients.

Item Type:	Article (Journal)
Additional Information:	4393/42712
Uncontrolled Keywords:	amputation, critical limb ischemia, peripheral transluminal angioplasty, PTA
Subjects:	R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Mrs Noor Azlin Asnam
Date Deposited:	05 May 2015 09:35
Last Modified:	17 Nov 2017 11:56
URI:	http://irep.iium.edu.my/id/eprint/42712

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