Preliminary characterization of plga scaffold for interverterbral discs tissue engineering

Mohamad, Mohd Yusof and Md Nazir, Noorhidayah and Abdul Rahman, Rozlin and Mohamad Syukri, Norhamiza and Ahmad Radzi, Muhammad Aa'zamuddin and Zulkifly, Ahmad Hafiz and Sha'ban, Munirah (2014) Preliminary characterization of plga scaffold for interverterbral discs tissue engineering. Regenerative Research, 3 (2). pp. 160-162. ISSN 2232-0822 (Online)

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Abstract

Poly(lactic-co-glycolic acid) or (PLGA) has attracted considerable interest for biomedical applications due to its biodegradability and approval for clinical use. This study aimed to characterize PLGA in terms of swelling capacity, compression test and scanning electron microscopy (SEM). The PLGA scaffold was fabricated using the solvent casting, salt leaching technique. For swelling test, the scaffolds were subjected to soaking in water for 48 hours. Compression test was performed using Instron E300 Machine. Results indicated that PLGA had swelling ability more than 100% [201.82%±48.51]. Compressive strength of PLGA showed average load of 84.01N±39.33. SEM demonstrated interconnected pores in the scaffold. Further tests need be done to characterize PLGA and its combination with other materials in terms of degradation and thermal properties.

Item Type:	Article (Journal)
Additional Information:	6006/41427
Uncontrolled Keywords:	PLGA,Swelling test,Compression,Scanning electron microscop
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Munirah Sha'ban
Date Deposited:	12 Feb 2015 14:57
Last Modified:	12 Feb 2015 14:57
URI:	http://irep.iium.edu.my/id/eprint/41427

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