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Studies on bactericidal efficacy of pumpkin (Cucurbita moschata Duchesne) peel

Ahmed, Qamar Uddin and Helaluddin, Abul Bashar Mohammed and Khan Chowdhury, Ahmed Jalal (2014) Studies on bactericidal efficacy of pumpkin (Cucurbita moschata Duchesne) peel. Journal of Coastal Life Medicine, 2 (2). pp. 146-153. ISSN 2309-6152 (O), 2309-5288 (P)

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Abstract

Objective: To explore the in vitro antibacterial potential of the peel of Cucurbita moschata Duchesne (tropical pumpkin) (C. moschata) against human pathogenic bacteria. Methods: In the present study, dichloromethane (DCM), methanol (MEOH) and aqueous extracts of C. moschata peel were examined for in vitro antibacterial potency against eight bacterial strains i.e. Bacillus cereus, Burkholderia cepacia, Escherichia coli, Enterococcus faecalis, Staphyloccocus aureus, Pseudomonas aerugenosa, Vibrio alginolyticus, Vibrio parahaemolyticus using Kirby- Bauer disk diffusion susceptibility and broth micro-dilution methods. Results: DCM extract of pumpkin peel exhibited the maximum zone of inhibition against Staphyloccocus aureus (21 mm) whereas aqueous extract of pumpkin peel revealed the least zone aofg aininhsitb iPtisoenu daogmaionnsta sE sacehreurgicehnioas ac o(l1i9 ( 8m mmm). ).B MroEtOhH m eixctrroa-cdt igluavtieo nm amxeimthuomd szhoonwe eodf imnihnibimituiomn imnihniibmituomry bcaocntceernictirdaatilo cno fnocre tnhtera tDioCnMs ewxetrraec at lasgo adinestet rBmuinrkehdo tlod ekrinao wce pthaec inaa atut r6e. 2o5f malgl /emxLtr.a Tchtse. DCM and MEOH extracts exhibited bactericidal nature to all bacterial strains except for the Vibrio alginolyticus. The minimum bactericidal concentrations values exhibited bactericidal nature reaxntrgaicntgs forfo mC. 3m.1o2s cmhga/tma Lp etoe l 1r0e0v.0e0a lmedg /tmhaLt. tThhee D sCcMre eexntirnagc to pf oasnsteismsiecdr ogboioadl parnotpimeritcireosb oiaf l deiffffiecraecnyt compared to MEOH and aqueous extracts. Conclusions: Peel of C. moschata possesses antibacterial compounds and could be potential source for a new class of antibiotics.

Item Type: Article (Journal)
Additional Information: 4921/41376
Uncontrolled Keywords: Cucurbita moschata, Pumpkin peel, Antibacterial activity, Pathogenic bacteria, Foodborne diseases
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Science > Department of Marine Science
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 05 Mar 2015 10:37
Last Modified: 06 Dec 2017 13:15
URI: http://irep.iium.edu.my/id/eprint/41376

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