Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi

Ahmed, Qamar Uddin and Parveen, Nazneen and Khan, N. U. and Singhal, K. C. (2002) Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi. Journal of Ethnopharmacology, 82 (1). pp. 23-28. ISSN 0378-8741

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Abstract

The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds caused the inhibition of spontaneous movements of the whole worm and the nerve muscle preparation of S. cervi , characterised by initial, short lasting small increase in tone of contractions followed by paralysis. The initial stimulatory effect was not observed by alcohol extract of leaves on nerve muscle preparation. The concentrations required to inhibit the movements of whole worm and nerve muscle preparations for alcohol extracts of leaves and seeds were 160, 30, and 150, 20 mg/ml, respectively suggesting a cuticular permeability barrier. Alcohol extracts of both leaves and seeds caused death of microfilariae in vitro, LC50 and LC90 being 15 and 25 ng/ml for alcohol extract of leaves and 12 and 18 ng/ml for alcohol extract of seeds,respectively.

Item Type:	Article (Journal)
Additional Information:	4921/41004
Uncontrolled Keywords:	Psoralea corylifolia, Setaria cervi, Antifilarial activity, Microfilaricidal
Subjects:	Q Science > QL Zoology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	11 Mar 2015 09:41
Last Modified:	11 Mar 2015 09:41
URI:	http://irep.iium.edu.my/id/eprint/41004

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