Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats

Kaleem, Mohammed and Medha, P. and Ahmed, Qamar Uddin and Asif, Mohd S. and Bano, Bilqees (2008) Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal, 49 (10). pp. 800-804. ISSN 0037-5675

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Abstract

Introduction: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ) -induced diabetes mellitus in rats. Methods: The effects of an aqueous extract of A. squamosa leaves on blood glucose, insulin, C-peptide, albumin, albumin/globulin ratio, urea, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Results: Oral administration of A. squamosa (300 mg/kg) aqueous extract to diabetic rats for 30 days significantly reduced blood glucose, urea, uric acid and creatinine, but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. Conclusion: The present results shown that A. squamosa extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.

Item Type:	Article (Journal)
Additional Information:	4921/40987
Uncontrolled Keywords:	Annona squamosa, blood glucose, diabetes mellitus, insulin
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	10 Mar 2015 08:48
Last Modified:	10 Mar 2015 08:48
URI:	http://irep.iium.edu.my/id/eprint/40987

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