A statistical framework for identifying past PRDM9 binding targets in primates

Tumian, Afidalina and Myers, Simon (2014) A statistical framework for identifying past PRDM9 binding targets in primates. In: International Conference on Computer & Communication Engineering 2014 (ICCCE 2014) , 23-25 September 2014, Kuala Lumpur. (Unpublished)

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Abstract

Recombination is a basic biological force, which, with mutation, plays an important role in generating new combinations of alleles in each chromosome, by shuffling and exchanging genetic material between maternal and paternal chromosomes. Multiple lines of evidence suggest that the rapidly evolving zinc-finger (ZF) protein, PRDM9, is responsible for initiating much or all of recombination in human. PRDM9 shows extreme variation in both the number and sequence of its ZFs, between species and amongst individuals, across mammals. The rapid evolution of the PRDM9 ZF array may be a response to escape a self-destructive drive called biased gene conversion, which can cause preferential transmission of hotspot disrupting alleles, and leading to erosion of vital recombination sites – and hotspot signaling motifs – in the genome through time. This research attempts to uncover ancestral PRDM9 binding targets in humans and primates. By using six primate genomes, this work involves the development of statistical methods that identifies the locations where meiotic recombination could have occurred in the past. This is achieved by looking for short words that have undergone rapid losses or gains in each lineage. As a result, we found many short and different words across lineages. In conclusion, our findings imply a rapidly evolving mechanism landscape of past PRDM9 binding targets.

Item Type:	Conference or Workshop Item (Full Paper)
Additional Information:	4915/40420
Uncontrolled Keywords:	biased gene conversion, meiotic recombination,crossing-over, evolution, genetic, DN
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Electrical and Computer Engineering
Depositing User:	Dr Afidalina Tumian
Date Deposited:	04 Feb 2015 10:08
Last Modified:	04 Feb 2015 10:10
URI:	http://irep.iium.edu.my/id/eprint/40420

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