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Adiponectin correlates in Malaysians: a comparison of metabolic syndrome and healthy respondents

Md Aris, Mohd Aznan and Khattak, Muhammad Muzaffar Ali Khan and Abdullah, Nor Zamzila and Mohd Rus, Razman and Draman, Samsul (2014) Adiponectin correlates in Malaysians: a comparison of metabolic syndrome and healthy respondents. American Journal of Clinical Medicine Research, 2 (6). pp. 106-110. ISSN 2328-4005 (P), 2328-403X (o)

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Several studies have demonstrated that adiponectin has strong association with metabolic syndrome and its factors like obesity, insulin resistance, type 2 diabetes, dyslipidemia and coronary artery disease. A total 152 subjects were registered in this study. Among the respondents 76 were with metabolic syndrome (based on the criteria of the International Diabetes Federation (IDF) world-wide definition) and another 76 matching healthy respondents. The factors which were studied for possible differences and association include central obesity (body mass index (BMI) & waist circumference (WC), hypertension (systolic blood pressure (SBP), diastolic blood pressure (DBP), dyslipidemia (total cholesterol (Tc), high density lipoprotein Cholesterol (HDL-c), low density lipoprotein Cholesterol (LDL-c), Triglyceride (TG) and Adiponectin (AD), fasting plasma glucose and history of smoking. The data collected was statistically analyzed using SPSS statistical software version 12.0. Two tests were performed including paired t-test and Pearson correlation analysis. The collected data revealed some interesting differences for the healthy and metabolic syndrome respondents. There were significant (P<0.01) differences for central obesity and hypertension. There were also significant (P<0.01, P<0.1, P<0.01) differences for TG, HDL and fasting plasma glucose. More importantly, AD concentration was significantly (P<0.05) higher in normal healthy respondents. The AD showed strong negative association (r = - 2.91, P<0.001) with FBG and positive association (r = 2.89, P<0.001) with HDL-c. The present study provides baseline information on the predication of metabolic syndrome in Malaysian population.

Item Type: Article (Journal)
Additional Information: 4632/40261
Uncontrolled Keywords: adiponectin, abdominal obesity, metabolic syndrome, hypertension, dyslipidemia
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Depositing User: Prof Dr Mohd Aznan Md Aris
Date Deposited: 27 Dec 2014 21:23
Last Modified: 25 Feb 2016 11:07
URI: http://irep.iium.edu.my/id/eprint/40261

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