Microscopic diffusion properties of fixed breast tissue: preliminary findings

Norddin, Narina and Power, Carl and Watson, Geoffrey and Cowin, Gary and Kurniawan, Nyoman and Gluch, Laurence and Bourne, Roger (2014) Microscopic diffusion properties of fixed breast tissue: preliminary findings. Magnetic Resonance in Medicine, xx (xx). pp. 1-7. (In Press)

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Abstract

Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples. Results: Diffusion-weighted images and mean diffusivity maps demonstrated distinct diffusivity differences between breast tissue components. Mean diffusivity (MD) in normal tissue was 0.5960.24 mm2/ms for gland lobule (voxels containing epithelium and intralobular stroma) and 1.2360.34 mm2/ms for interlobular fibrous stroma. In the cancer samples, MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels contain epithelium and intralobular stroma) and 0.6160.35 mm2/ms for ductal carcinoma in situ. There were significant MD differences between all tissue components (P<0.005), except between gland lobule and ductal carcinoma in situ (P¼0.71). The low diffusivity of epithelium-rich cancer tissue and of normal epithelium relative to its supporting fibrous stroma was similar to that reported for prostate tissue and the esophageal wall. Conclusion: Diffusion microimaging demonstrates distinct diffusivity differences between breast tissue glandular structures. Low diffusivity may be a distinctive feature of mammalian epithelia.

Item Type:	Article (Journal)
Additional Information:	5181/40078
Uncontrolled Keywords:	diffusion;microimaging;breast;DTI
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Diagnostic Imaging and Radiotherapy
Depositing User:	Narina Norddin
Date Deposited:	29 Jan 2015 17:06
Last Modified:	23 May 2018 11:28
URI:	http://irep.iium.edu.my/id/eprint/40078

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