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Cytotoxic tirucallane triterpenes from the stem of luvunga scandens

Al Zikri, Putri Nurhidayah and Bakhtiar, M. Taher and Darnis, Deny Susanti and Rezali, Mohd Fazlin and Read, Roger W and Sohrab, Md. Hossain and Hasan, Choudhury Mahmood and Ahmad, Farediah (2014) Cytotoxic tirucallane triterpenes from the stem of luvunga scandens. Brazilian Journal of Pharmacognosy, 24 (5). pp. 561-564. ISSN 0102-695X

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Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 2 were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respec- tively. This result suggested their potential activity as antitumor agents.

Item Type: Article (Journal)
Additional Information: 5209/40039
Uncontrolled Keywords: Triterpenes, Cytotoxicity, Luvunga scandens, Tirucallane
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Muhammad Taher
Date Deposited: 21 Dec 2014 14:24
Last Modified: 19 Sep 2017 15:17
URI: http://irep.iium.edu.my/id/eprint/40039

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