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Kesan in vitro rilmenidine ke atas rembesan insulin

Hashim, Rosnani and Abdul Razak, Tariq and Hashim, Suhaimi (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1. pp. 1-7. ISSN 1675-8161

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Abstract

This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.

Item Type: Article (Journal)
Additional Information: 1798/400
Uncontrolled Keywords: Rilmenidine; isolated pancreas; insulin secretion; peak plasma concentration
Subjects: R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine
Depositing User: Mr Suhaimi Hashim
Date Deposited: 08 Aug 2011 08:44
Last Modified: 08 Aug 2011 08:44
URI: http://irep.iium.edu.my/id/eprint/400

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