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Antibacterial efficacy of Bacopa monnieri leaf extracts against pathogenic bacteria

Khan, Abdul Viqar and Ahmed, Qamar Uddin and Shukla, Indu and Khan, Athar Ali (2010) Antibacterial efficacy of Bacopa monnieri leaf extracts against pathogenic bacteria. Asian Biomedicine, 4 (4). 651-655.. ISSN 1905-7415

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Background: Bacopa monnieri (Linn) Pennell (Scrophulariaceae) is widely distributed in tropical regions of Asia, and used in the treatment of cough or as an antiseptic. The traditional use of this plant suggests its possible antibacterial properties, but its efficacy has not been examined yet. Objective: Evaluate the antibacterial efficacy against pathogenic bacteria using the disk diffusion method. Materials and methods: Five different concentrations (500 μg, 1, 2, 5, 10, and 15 mg/mL) of crude leaf extracts of Bacopa monnieri (L.) Pennell were tested for antibacterial efficacy against seven Gram-positive and 11 Gramnegative bacteria. The sensitivity of plant fractions was tested using the disk diffusion method. Results: Maximum activity was revealed by ethyl acetate and methanol extracts, followed by aqueous, benzene, and petrol extracts. Phyto-chemical analysis of the plant leaf showed the presence of alkaloids, flavonoids, and saponins. Conclusion: This plant may be effective for treatment of different pathogenic diseases. Keywords: Antibacterial efficacy, Bacopa monnieri (L.) Pennell, crude extracts, traditional use

Item Type: Article (Journal)
Additional Information: 4921/3990
Uncontrolled Keywords: antibacterial efficacy, bacopa monnieri (L.) pennell, crude extracts, traditional use
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr Qamar Uddin Ahmed
Date Deposited: 29 Sep 2011 11:50
Last Modified: 27 Jan 2012 10:07
URI: http://irep.iium.edu.my/id/eprint/3990

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