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Impact of thymoquinone supplementation on immobilisation stress-induced changes in reproductive characteristics of male mice

Abdul Rahman, Suzanah and Mohamed Anwar, Norul Athirah and Shaik , Sadak Basha and Kamarzaman, Saheera (2014) Impact of thymoquinone supplementation on immobilisation stress-induced changes in reproductive characteristics of male mice. Journal of Applied and Natural Science, 6 (1). pp. 1-5. ISSN 0974-9411 (P); 2231-5209 (O)

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Abstract

The aim of the current study was to investigate changes in the reproductive parameters during stress and the impact of thymoquinone during the period. The effects of stress were measured through immobilisation stress on mice. Group I was administered normal saline daily via intraperitoneal injection while Groups II and III were subjected to 2 and 6 hours of immobilisation stress respectively. Groups IV and V were subjected to stress for 2 and 6 hours respectively followed by intraperitoneal injection of 10 mg/kg thymoquinone which was continued on alternate days. The level of significance was set at p<0.05 and statistical analysis showed significant difference in testicular weight of mice in groups II and III compared to the controls but no significant difference was obtained for sperm count between all groups. Sperm motility, however, was significantly different among the groups under stress for 2 and 6 hours and that of 6 hours with the treatment of thymoquinone when compared to the controls. The histology of the testes also indicated a few alterations in comparison to the controls in the germinal epithelium and spermatogenic pattern in groups III and V.

Item Type: Article (Journal)
Additional Information: 4493/39098
Uncontrolled Keywords: Histopathology, Immobilisation Stress, Male mice, Sperm, Testis, Thymoquinone
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Depositing User: Assoc. Prof. Dr. Suzanah Abdul Rahman
Date Deposited: 25 Nov 2014 16:00
Last Modified: 01 Sep 2015 01:59
URI: http://irep.iium.edu.my/id/eprint/39098

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