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Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga

Omar, Muhammad Nor and Mohd Hasali, Nor Hazwani and Alfarra, Helmi Yousif and Yarmo, Mohd Ambar and Zuberdi, Ahmad Muzammil (2014) Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga. Oriental Journal of Chemistry, 30 (3). pp. 1037-1043. ISSN 0970 - 020X (P), 2231-5039 (O)

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Abstract

Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active against both Staphylococcus aureus and Bacillus cereus at MIC 333 μg/ml while against Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 μg/ml. It was also shown that EPHC exhibited more growth inhibition potential than EPMC. Besides that, EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 μg/mL while EPMC did not show killing potential toward the tested microorganisms.

Item Type: Article (Journal)
Additional Information: 5626/38610
Uncontrolled Keywords: Biotransformation, Kaempferia galanga Linn, Ethyl p-methoxycinnamate, Ethyl ρ- hydroxycinnamate, Aspergillus niger, Antimicrobial
Subjects: Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Science > Department of Biotechnology
Depositing User: Prof Dr Muhammad Nor Omar
Date Deposited: 07 Oct 2014 15:11
Last Modified: 19 Jun 2018 09:57
URI: http://irep.iium.edu.my/id/eprint/38610

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